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Neuropathy Study Results: 800 People Rate 35 Treatments

For the live-updated, interactive version of this infographic, click here.

The scattering of points on this chart suggests that Neuropathy is a poorly understood condition.

Why? Well, if it was well understood how to treat Neuropathy, the most effective treatments would also be the most popular, and there would be a nice straight line of points from the top right to the bottom left. Instead, there’s a wide scatter, with some patients finding unpopular solutions that are very effective.

At CureTogether, 803 patients with Neuropathy came together to rate 35 treatments. Here are the current results of this ongoing study.

Patients rate Cymbalta, Neurontin, TENS, and Capsaicin cream as making their Neuropathy worse, not better (see the red part of the chart above.)

The treatments that help most, at the top of the green part of the chart, are: physical therapy, Low-Dose Naltrexone, and water exercise.

While this is just one study, it suggests that more knowledge needs to be gathered on how to best treat Neuropathy, including non-drug treatment options.

The rest of the results are in the graph above, which is divided into four squares…

- Top right: the most popular and effective treatments (including standing up slowly and avoiding smoking)

- Top left: effective treatments that not many people have tried, so they may be options to think about (including LDN and physical therapy)

- Lower right: very popular but not very effective (including Neurontin and vitamin D3)

- Lower left: neither popular nor effective (including Cymbalta and TENS)

Where did this data come from? This is the result of a 3-year CureTogether study on NeuropathyTo thank everyone for participating, we’re publishing this study openly and freely.

This is part of our regular series of research findings. Of course, with each of these findings, there is a potential bias in patient self-selection and recall. Every research study has some bias, so we present these findings as just what they are – patient-reported data – to stimulate discussion and generate new insights for further research.

Please tweet, blog, or pass this along to anyone who can benefit or is interested in Neuropathy. Thank you!

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14 Responses to “Neuropathy Study Results: 800 People Rate 35 Treatments”

  1. Marti Murphy Says:

    I have Fibromyalgia. A year ago, after having read a great deal online, I started taking LDN. It has worked wonders on all the varied symptoms of a horrible “condition”.

    I have found none of my online acquaintances nor friends locally have heard of it, and don’t want to. They keep on with their expensive and habit forming drugs.

    I cannot urge strongly enough that more patients try this CHEAP drug with no side effects! Don’t rely on your medical personnel — there is no $$$ in it for the medical community.

    I order it from River Pharmacy in Canada for $139 every nine months. It has been a miracle for me!

  2. Jeanne Owens Says:

    I have neuropathy from radiation treatment for chordoma of the L-5. I developed it about 7 years after my surgery and it is affecting both feet. I now have a cry hard time balancing myself being I have no feeling in the front part of both feet. I don’t know if anything can be done but it seems like nothing is helping. I am open to any suggestions.

  3. There is a problem with “b12″. Most b12 won’t work for neuropathy. ONLY methylcobalamin will work well. Only about 2 out of the many brands will work well. Those 2 will work well only if taken the right way. So the methylb12 of the two correct brands taken sublingually for 2 hours with the necessary cofactors like Metafolin, zinc, omega3 oils, adenosylcobalamin plus others can reliably and predictably produce astonishing results with neuropathy but every particular must bew exactly right. I know exactly how to do it and have helped a lot of others achieve excellent results. You don’t collect the right information to ever stumble upon the complete answer.

  4. Hi
    I am a 67 year old retired nurse, initailly diagnosed with polymyalagia rheumatica (PR) in 2007. I was prescribed steroids which I took for three years during which time I suffered massive weight gain and developed renal stones. Following numerous blood test which were now inconsistent with PR, I eventually requested stopping the steroids. In 2010 following consultation with my GP and hospital consultant, I commenced on B12 therapy and Omega 3 fish oil. This combination I feel has worked wonders. I no longer suffer the muscle pains or renal problems. However, it is proving difficult to reduce the extra weight gain caused by the steroids. Prior to my retirement, I participated in a health study one test which showed a borderline B12 deficiency. My GP ensured me this was of no concern. However, I now wonder whether the initial diagnosis of Polymyalagia was correct or if my low B12 was ultimately the cause of my problems.

  5. I purchased the ReBuilder Treatment System ( Since I’ve started using it, I’ve regained movement in my toes, which were previously numb and lifeless. I can now feel temperatures again, and I even walk better at times without my cane though I am still careful since I have lymphedema in the same leg as a result of post-radiation burn for colorectal cancer surgery! The greatest result from this treatment is that it has virtually eliminated all of the painful neuropathy symptoms. I am so grateful to God for this and for finally gaining some relief. You can visit or write to me through my blog if you have any questions about my story.

    See Insurance/medicare form:

    This SHOULD NOT be used on TENS unit setting for neuropathy. You should follow instructions and make incremental increases in your treatment under guidance of your doctor and according to The Rebuilter Treatment instructions.

    Special safety alert: There is only one ReBuilder, and you should be careful not to accept any substitutes such as a regular TENS or cheap, imported, socks or gloves.

  6. I just heard that ALA (Alpha lipoic acid) will cure neuropathy. Anyone know about that?
    I took B12 shots 2 years ago for it, which I think was caused by a heart medication, or HIV, which I didn’t know I had at the time. It went away.

  7. I wonder why lipoic acid isn’t listed. Are there really so few people taking it for neuropathy? It completely got rid off the mild neuropathic “gnawing” pain in my legs (caused by CFS/ME) and studies show efficacy in diabetic neuropathy.

  8. Thanks for the question, Rod and Maija! Alpha-Lipoic Acid is part of the Neuropathy survey (see results here –, but so far only 20 people have reported using it, so we don’t yet have enough data on it for it to be included in this chart.
    Alex :)

  9. [...] can be difficult. An interesting study of treatments for neuropathy was published last week by CureTogether. The treatments were rated by patients, and found that some of the most prevalent treatments, like [...]

  10. What symptoms of fibromyalgia has LDN helped? Does anyone know? Fatigue? Pain? Any info would be helpful!

  11. Clive Francis Says:

    Very interested in ” Fred ” and his observation on methylb12. I am using this but would certainly like to take up his positive ‘menu’ to get beneficial results. Will Fred share it, please? With reference to the rebuilder. I have found that when my toes become lifeless little curled up sausages at the end of my feet then using the rebuilder quickly enables them to be more supple and respond better to my trying to move them. They do indeed sit flatter and straighter on the floor. As far as the neuropathic pain is involved I still suffer badly with it despite the rebuilder, but I might not be using it properly as I am very erratic in my undisciplined self treatment regimen. I have used ALA but have left off using it because my problem with diarrhea increased, I think that the Metformin I use causes this and the ALA just helped the increase. I did not use it long enough to evaluate if it would help. Unfortunately my neuropathic pain and debilitating effect it has on me has not seemed to have subsided one jot at the moment. But I am still ever hopeful that some time in the future by keeping at these regimens it will improve.

  12. dorothy barna Says:

    I still have not got an answer on what to do for my neuropathy please help

  13. Sorry that the gluten free diet is not higher on the list for neuropathy. Eight years ago I was having difficulty walking. My pain in my feet was so great I had to sleep with my feet dangling off the side of the bed so nothing touched them. I then read some articles linking gluten sensitivity with neuropathy. I went on a gluten free diet and now my pain level is 0-1 and my feet no longer slow me down. Then 3 years ago I bought a glucometer and discovered my postprandial blood sugars were spiking over 200. I am now on a low carbohydrate diet that controls my blood sugar along with being gluten/grain free. My health has made a great turn around.

  14. If you were to take “b12″ out of a single category and become aware that both methylb12 and adenosylb12 are essential to healing neuropthy performing different functions and that only perhaps 2 brands of methylb12 are useful in this then the results would appear different. Cyanocobalamin and hydroxycobalamin are faux vitamins and don’t affect neuropathy in the vast majority of people and only a little in a few people. This dilutes the results to uselessness.

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